2013 Publications

 

1 Kinetic Resolution of β-Substituted Olefinic Carboxylic Acids by Asymmetric Bromolactonization
K. Murai, T. Matsushita, A. Nakamura, N. Hyogo, J. Nakajima, H. Fujioka
Organic Letters (2013), 15(10), 2526-2529.
Figure
2 Asymmetric Dearomatizing Spirolactonization of Naphthols Catalyzed by Spirobiindane-Based Chiral Hypervalent Iodine SpeciesT. Dohi, N. Takenaga, T. Nakae, Y. Toyoda, M. Yamasaki, M. Shiro, H. Fujioka, A. Maruyama, Y. Kita
Journal of the American Chemical Society (2013), 135(11), 4558-4566.
3 Methylene acetal formation from 1,2- and 1,3-diols using an O,S-acetal, 1,3-dibromo-5,5-imethylhydantoin, and BHTCyclopropanes
T. Maegawa; Y. Koutani; K. Otake; H. Fujioka
Journal of organic chemistry (2013), 78(7), 3384-90.2013_003
4 Remarkable effect of CF3CH2OH for the halogen induced oxidative rearrangement reaction of aminals leading to 3,4-dihydroquinazolines
K. Murai, M. Shimura, R. Nagao, D. Endo, H. Fujioka
Organic & Biomolecular Chemistry (2013), 11(16), 2648-2651.Graphical abstract: Remarkable effect of CF3CH2OH for the halogen induced oxidative rearrangement reaction of aminals leading to 3,4-dihydroquinazolines
5 Methodology for in situ protection of aldehydes and ketones using trimethylsilyl trifluoromethanesulfonate and phosphines: selective alkylation and reduction of ketones, esters, amides, and nitriles
Yahata Kenzo; Minami Masaki; Yoshikawa Yuki; Watanabe Kei; Fujioka Hiromichi
Chemical & Pharmaceutical bulletin (2013), 61(12), 1298-307.
6 One-Pot Ring-Closing Metathesis (RCM)/1,3-Dipolar Cycloaddition by an Assisted Tandem Ruthenium Catalysis for the Synthesis of a Novel Dye of Isoindolo[2,1-a]quinoline Structure
Arisawa, Mitsuhiro; Fujii, Yuki; Kato, Hiroshige; Fukuda, Hayato; Matsumoto, Takashi; Ito, Mika; Abe, Hiroshi; Ito, Yoshihiro; Shuto, Satoshi
Angewandte Chemie, International Edition (2013), 52(3), 1003-1007.Thumbnail image of graphical abstract
7 Suzuki–Miyaura cross-coupling reactions using a low-leaching and highly recyclable gold-supported palladium material and two types of microwave equipments
Mohammad Al-Amin, Masayoshi Akimoto, Tsuyoshi Tameno, Yuuta Ohki, Naoyuki Takahashi, Naoyuki Hoshiya, Satoshi Shuto, Mitsuhiro Arisawa
Green Chemistry (2013), 15(5), 1142-1145.Graphical abstract: Suzuki–Miyaura cross-coupling reactions using a low-leaching and highly recyclable gold-supported palladium material and two types of microwave equipments
8 Conformational Restriction Approach to BACE1 Inhibitors II: SAR Study of the Isocytosine Derivatives Fixed with a cis-Cyclopropane Ring
Shuji Yonezawa, Hidekuni Yamakawa, Chie Muto, Motoko Hosono, Takahiko Yamamoto, Kazunari Hattori, Masahiro Sakagami, Hiroko Togame, Yoshikazu Tanaka, Toru Nakano,Hiroshi Takemoto, Mitsuhiro Arisawa and Satoshi Shuto
Bioorganic & Medicinal Chemistry Letters (2013), 23(10), 2912-2915.image
9
Three-Dimensional Structural Diversity-Oriented Peptidomimetics Based on the Cyclopropylic Strain
Akira Mizuno, Shiho Miura, Mizuki Watanabe, Yoshihiko Ito, Shizuo Yamada, Takenao Odagami,Yuji Kogami, Mitsuhiro Arisawa, Satoshi Shuto
Organic Letters (2013), 15(7), 1686-1689.Figure
10
Potent Proteasome Inhibitors Derived from the Unnatural Cis-Cyclopropane Isomer of Belactosin A: Synthesis, Biological Activity, and Mode of Action
Shuhei Kawamura, Yuka Unno, Anja List, Motohiro Tanaka, Takuma Sasaki, Mitsuhiro Arisawa, Akira Asai, Michael Groll, Satoshi Shuto
Journal of Medicinal Chemistry (2013), 56(9), 3689-700.Figure
11
Design and Total Synthesis of Cyclic ADP-4-Thioribose as a Chemically and Biologically Stable Equivalent of Cyclic ADP-Ribose, a Ca2+-Mobilizing Second Messenger
Takayoshi Tsuzuki, Satoshi Takano, Natsumi Sakaguchi, Takashi Kudoh, Takashi Murayama, Takashi Sakurai, Minako Hashii, Haruhiro Higashida, Karin Weber Andreas H. Guse,
Barry V. L. Potter, Tomoshi Kameda, Takatsugu Hirokawa, Yasuhiro Kumaki, Mitsuhiro Arisawa, Satoshi Shuto
Angewandte Chemie, International Edition (2013), 52(26), 6633-6637.Link to full-size graphical abstract
12
Design Synthesis, and Validation of Peptidomimetics with Three-dimentional Structure Diversity
Akira, Mizuno, Shiho Miura, Mizuki Watanabe, Tomoshi Kameda, Mitsuhiro Arisawa, Satoshi Shuto
Peptide Science (2013), 49, 9-10.
13
DJ-1 cooperates with PYCR1 in cell protection against oxidative stress
Tatsuki Yasuda, Yusuke Kaji, Tomohiro Agatsuma, Takeshi Niki, Mitsuhiro Arisawa, Satoshi Shuto, Hiroyoshi Ariga, Sanae M.M. Iguchi-Ariga
Biochemical and Biophysical Research Communications (2013), 436(2), 289-294.
14
Investigation of the Non-Covalent Binding Mode of Covalent Proteasome Inhibitors around the Transition State by Combined Use of Cyclopropylic Strain-Based Conformational Restriction and Computational Modeling
Shuhei Kawamura, Yuka Unno, Motohiro Tanaka, Takuma Sasaki, Akihito Yamano, Takatsugu Hirokawa, Tomoshi Kameda, Akira Asai, Mitsuhiro Arisawa, Satoshi Shuto
Journal of Medicinal Chemistry (2013), 56(14), 5829-5842.Figure
15
Development of Second Generation Gold-Supported Palladium Material with Low-Leaching and Recyclable Characteristics in Aromatic Amination
Mohammad Al-Amin, Satoshi Arai, Naoyuki Hoshiya, Tetsuo Honma, Yusuke Tamenori, Takatoshi Sato, Mami Yokoyama, Akira Ishii, Masashi Takeuchi, Tomohiro Maruko, Satoshi Shuto, Mitsuhiro Arisawa
Journal of Organic Chemistry (2013), 78(15), 7575-81.Figure
16
Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transports
Kazuaki Nakada, Mamie Yoshikawa, Soichiro Ide, Akihiro Suemasa, Shuhei Kawamura, Takaaki Kobayashi, Eiji Masuda, Yoshihiko Ito, Wataru Hayakawa, Takahiro Katayama, Shizuo Yamada, Mitsuhiro Arisawa, Masabumi Minami, Satoshi Shuto
Bioorganic & Medicinal Chemistry (2013), 21(17), 4938-50.image
17
A fluorescence-based method for evaluating inositol 1,4,5-trisphosphate receptor ligands: Determination of subtype selectivity and partial agonist effects
Akihiko Tanimura, Tetsuya Mochizuki, Takao Morita, Nezu, Yosuke Tojyo, Mitsuhiro Arisawa, Satoshi Shuto
Journal of Biotechnology (2013), 167(3), 248-254.
18
Design and synthesis of the stabilized analogs of belactosin A with the unnatural cis-cyclopropane structure
Shuhei Kawamura, Yuka Unno, Akira Asai, Mitsuhiro Arisawa, Satoshi Shuto
Organic & Biomolecular Chemistry (2013), 11(38), 6615-6622.Graphical abstract: Design and synthesis of the stabilized analogs of belactosin A with the unnatural cis-cyclopropane structure
19
Conformational restriction approach to β-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations
Shuji Yonezawa, Kenichiro Fujiwara, Takahiko Yamamoto, Kazunari Hattori, Hidekuni Yamakawa, Chie Muto, Motoko Hosono, Yoshikazu Tanaka, Toru Nakano, Hiroshi Takemoto, Mitsuhiro Arisawa, Satoshi Shuto
Bioorganic & Medicinal Chemistry (2013), 21(21), 6506-6522.image
20
Preparation of nonracemic bromomethylenecyclopropane and its use in Suzuki-Miyaura coupling; synthesis of the arylmethyl-cis-cyclopropane structure core.
Makoto Tanabe, Mizuki Watanabe, Naoyuki Hoshiya, Akira Mizuno, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto
Journal of Organic Chemistry (2013), 78(23), 11714-11720.Figure
21
Palladium-Catalyzed Arylation of Cyclopropanes via Directing Group-Mediated C(sp3)–H Bond Activation To Construct Quaternary Carbon Centers: Synthesis of cis- and trans-1,1,2-Trisubstituted Chiral Cyclopropanes
Naoyuki Hoshiya, Takaaki Kobayashi, Mitsuhiro Arisawa, Satoshi Shuto
Organic Letters (2013), 15(24), 6202-6205.Figure

 

総説

1 Recent progress in organocatalytic asymmetric halocyclizationK. Murai, H. Fujioka
Heterocycles (2013), 87(4), 763-805.
2 ピリジニウム型塩中間体を経由するケタール類存在下でのアセタール類の脱保護と中間体への求核種導入反応前川 智弘、 藤岡 弘道
有機合成化学協会誌, 71, 694-705, 2013

特許

1 触媒前駆体、その製造方法、 その使用方法及びそれを用いたリアクター
有澤光弘,周東智,星谷尚亨、PCT/JP2010/062065.
2 フロー型触媒反応装置
有澤光弘,周東智,アルアミン モハンマド,高橋直行,大木裕太,秋元正寿,為野強士,星谷尚亨、特願2012-029091