大阪大学薬学部 医薬合成化学分野

2011 Publications

 

1 Intramolecular Iodoetherification of Ene or Diene Ketals: Facile Synthesis of Spiroketals
Hiromichi Fujioka, Kenji Nakahara, Hideki Hirose, Kie Hirano, Tomohiro Oki, Yasuyuki Kita
Chem. Commun. 47, 1060-1062 (2010)
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2 Phenyliodine diacetate-mediated oxidative cleavage of cyclobutanols leading to γ-hydroxy ketones
H. Fujioka, H. Komatsu, A. Miyoshi, K. Murai, Y. Kita
Tetrahedron Letters, 52, 973-975.(2011)
3 The reaction of acetal-type protective groups in combination with TMSOTf and 2,2′-bipyridyl; mild and chemoselective deprotection and direct conversion to other protective groupes
H. Fujioka,Y. Minamitsuji, O. Kubo, K. Senami, T. Maegawa
Tetrahedron, 67, 2949-2960. (2011)2011_003
4 Asynmmetric Total Synthesis of Clavolonine
K. Nakahara, K. Hirano, R. Maehata, Y. Kita, and H. Fujioka
Organic Letters, 2015-2017. (2011)

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5 C 3-Symmetric chiral trisimidazoline: the role of a third imidazoline and its application to the nitro Michael reaction and the α-amination of β-ketoesters
K.Murai, S.Fukushima, A.Nakamura, M. Shimura, H. Fujioka
Tetrahedron, 67, 4862-4868. (2011) 

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6 Efficient phenolic oxidations to construct ortho-spirolactone structures using oxo-bridged hypervalent iodine(III) compound
N. Takenaga; T. Uchiyama; D. Kato, H. Fujioka, T. Dohi; Y. Kita
Heterocycles, 82, 1327-1336. (2011)
7 The Synthetic and biological studies of discorhabedins and related compounds
Y. Wada, Y, Harayama, D. Kamimura, M. Yoshida, T. Shibata, K. Fujiwara; K. Morimoto, H. Fujioka, Y. Kita
Organic & Biomolecular Chemistry, 9, 4959-4976. (2011)
8 Direct conversion of acetals to esters with high regioselectivity via O,P-acetals
T. Maegawa, K. Otake, A. Goto, H. Fujioka
Organic & Biomolecular Chemistry, 9, 5648-5651. (2011)
Graphical abstract: Direct conversion of acetals to esters with high regioselectivity via O,P-acetals
9 2,5-cis-2,3,5-Trisubstituted tetrahydrofurans from the diastereomixture of 2,4-disubstituted 1,3-dioxepins via stereomutation
O. Kubo, K. Yahata, T. Maegawa, H. Fujioka
Chemical Communications, 47, 9197-9199. (2011)
Graphical abstract: 2,5-cis-2,3,5-Trisubstituted tetrahydrofurans from the diastereomixture of 2,4-disubstituted 1,3-dioxepins via stereomutation
10 An unusual reaction of α-alkoxyphosphonium salts with Grignard reagents under an O2 atmosphere
H. Fujioka, A. Goto, K. Otake, O. Kubo, Y. Sawama, T. Maegawa
Chemical Communications, 47, 9894-9896. (2011)Graphical abstract: An unusual reaction of α-alkoxyphosphonium salts with Grignard reagents under an O2 atmosphere
11 Reversing the Reactivity of Carbonyl Functions with Phosphonium Salts:
Enantioselective Total Synthesis of (+)-Centrolobine
H. Fujioka, K. Yahata, O. Kubo, Y. Sawama, T. Hamada, T. Maegawa
Angewante Chemie International Edition, 50, 12232-12235. (2011)
Thumbnail image of graphical abstract
12 Metal-free C-H cross-coupling toward oxygenated naphthalene-benzene linked biaryls
T. Dohi, M. Ito, I. Itani, N. Yamaoka, K. Morimoto, H. Fujioka, Y. Kita
Organic Letter, 13, 6208-6211. (2011)