| I. | Paper |
| 1 | Selective Reduction and Dihydroxylation of α,β-Unsaturated Esters in The Presence of Enals: One-Pot Synthesis of A 2,5-Disbstituted Tetrahydrofuran Kenta Morita, Kenichi Murai, Mitsuhiro Arisawa, and Hiromichi Fujioka* Heterocycles 2021, 103, 311-321. DOI: 10.3987/COM-20-S(K)15  |
| 2 | Conjugate Addition Reaction of Indole to Protected 2-Amino-1-Nitroethenes Mediated by Silica Gel Kenichi Murai,* Shuji Miyazaki, and Hiromichi Fujioka* Heterocycles 2021, 103, 459-464. DOI: 10.3987/COM-20-S(K)5  |
| 3 | Design, Synthesis, Physical Properties and Indoleamine 2, 3-Dioxygenase 1 Inhibitory Activity of Substituted Indole Derivatives with N-H, N-Metohymethyl, or N-Mehylthiomethyl Group toward Fragment-Based Drug Discovery Kenta Hayami#, Yuichi Kuboki#, Katsumi Ohta, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Jun-Ichi Haruta , Kenichi Murai, Hiromichi Fujioka, Akira Asai, and Mitsuhiro Arisawa* # Equal contribution Heterocycles 2021, 103, 511-525. DOI: 10.3987/COM-20-S(K)35  |
| 4 | Total Synthesis and Biological Evaluation of the Potent HIV Latency-Reversing Agent Ansellone A and its Analogues Mizushi Yanagihara, Kenichi Murai*, Naoki Kishimoto, Towa Abe, Shogo Misumi, Mitsuhiro Arisawa* Org. Lett. 2021, 23, 1720–1725. DOI: 10.1021/acs.orglett.1c00151  |
| 5 | Structure-activity Relationship of Indomethacin Derivatives as IDO1 Inhibitors Tohru Obata, Sara Shiratani, Tomomi Nada, Yayoi Kasaya, Mitsuhiro Arisawa, Satoshi Shuto, Motohiro Tanaka Anticancer Res. 2021, 41, 2287-2296. DOI: 10.21873/anticanres.15004  |
| 6 | Iridium-Catalyzed Isomerization/Cycloisomerization/Aromatization of N-Allyl-N-sulfonyl-o-(λ1-silylethynyl)aniline Derivatives to Give Substituted Indole Derivatives Jiawei Qiu, Makoto Sako, Tomoyuki Tanaka, Tsuyoshi Matsuzaki, Tsunayoshi Takehara, Takeyuki Suzuki, Shohei Ohno, Kenichi Murai, Mitsuhiro Arisawa* Org. Lett. 2021, 23, 4284–4288. DOI: 10.1021/acs.orglett.1c01231  |
| 7 |
Revisiting Chiral Recognition Mechanism on Chicken Alpha 1-Acid Glycoprotein: Location of Chiral Binding Sites and Insight into Chiral Binding Mechanism |
| 8 | A New Bitterness Evaluation Index Obtained Using the Taste Sensor for 48 Active Pharmaceutical Ingredients of Pediatric Medicines Honami Kojima, Toshio Kurihara, Miyako Yoshida, Tamami Haraguchi, Haruka Nishikawa, Saeri Ikegami, Takayoshi Okuno, Taku Yamashita, Junichi Nishikawa, Hirofumi Tsujino, Mitsuhiro Arisawa, Masaaki Habara, Hidekazu Ikezaki, Takahiro Uchida* Chem. Pharm. Bull. 2021, 69, 537-547. DOI: 10.1248/cpb.c20-01014  |
| 9 | Chemo- and Enantioselective Hetero-coupling of Hydroxycarbazoles Catalyzed by a Chiral Vanadium(v) Complex Makoto Sako, Keigo Higashida, Ganesh Tatya Kamble, Kevin Kaut, Ankit Kumar, Yuka Hirose, Dayang Zhou, Takeyuki Suzuki, Magnus Rueping, Tomohiro Maegawa, Shinobu Takizawa*, Hiroaki Sasai* Org. Chem. Front. 2021, 8, 4878-4885. DOI: 10.1039/D1QO00783A |
| 10 | Preparation of a Platinum Nanoparticle Catalyst Located Near Photocatalyst Titanium Oxide and Its Catalytic Activity to Convert Benzyl Alcohols to the Corresponding Ethers Yuki Wada, Toshiki Akiyama, Kazuo Harada, Tetsuo Honma, Hiroshi Naka, Susumu Saito, Mitsuhiro Arisawa* RSC Adv. 2021, 11, 22230–22237. DOI: 10.1039/d1ra00988e  |
| 11 | Carbon-Carbon Bond Formation Between Nitrogen-Containing Heterocyclic Carbene (NHC) Ligand on Ruthenium Carbene Catalysts and 1,4-Naphthoquinone via Intramo-lecular Carbon(sp3)-Hydrogen Bond Activation Yuki Wada, Tsunayoshi Takehara, Takeyuki Suzuki, Satoshi Aoki, Takayuki Hibi, Makoto Sako, Hirofumi Tsujino, Yasuo Tsutsumi, Mitsuhiro Arisawa* Organometallics 2021, 40, 2901-2908. DOI: 10.1021/acs.organomet.1c00350  |
| 12 | Design, Synthesis, and Monoamine Oxidase Inhibitory Activity of (+)-Cinchonaminone and Its Simplified Derivatives Yuta Sato#, Naoko Oyobe#, Takao Ogawa, Sayo Suzuki, Hiroshi Aoyama, Tomonori Nakamura, Hiromichi Fujioka, Satoshi Shuto, Mitsuhiro Arisawa* # Equal contribution ACS Med. Chem. Lett. 2021, 12, 1464–1469. DOI: 10.1021/acsmedchemlett.1c00310  |
| 13 | Inhibitory Activity and Proposed Binding Model of γ-Glutamyl Cysteine, the Precursor of Glutathione, on Angiotensin Converting Enzyme Chisato Okajima, Naoki Imakawa, Kazuya Nagano*, Masayoshi Arai, Mitsuhiro Arisawa, Misa Muraoka, Hirofumi Tsujino, Yoshihiko Hirata, Kazumasa Hirata* BPB Reports 2021, 4, 116-119. DOI: 10.1248/bpbreports.4.4_116  |
| 14 | Product Selective Reaction Controlled by the Combination of a Palladium Nanoparticles, Continuous Microwave Irradiation, and a Co-existing Solid; Ligand-Free Buchwald–Hartwig Amination vs Aryne Amination Makito Yamada, Ryousuke Ohta, Kazuo Harada, Tsunayoshi Takehara, Hitoshi Haneoka, Yosuke Murakami, Takeyuki Suzuki, Yuuta Ohki, Naoyuki Takahashi, Toshiki Akiyama, Natchanun Sirimangkalakitti, Makoto Sako, Kenichi Murai, Masayoshi Arai, Mitsuhiro Arisawa* Green. Chem. 2021, 8131-8137. DOI: 10.1039/D1GC01782A【Open Access】  |
| 15 | Chemo- and Regioselective Cross-dehydrogenative Coupling Reaction of 3-Hydroxycarbazoles with Arenols Catalyzed by a Mesoporous Silica-supported Oxovanadium Kengo Kasama, Kyohei Kanomata, Yuya Hinami, Karin Mizuno, Yuta Uetake, Toru Amaya, Makoto Sako, Shinobu Takizawa, Hiroaki Sasai, Shuji Akai* RSC Adv. 2021, 11, 35342-35350. DOI: 10.1039/D1RA07723F 【Open Access】 |
| Ⅱ. | Review |
| 1 | “ヘテロ原子が直接結合したオレフィンを反応点とする炭素環・ヘテロ環合成法；芳香環につながれた2つの多重結合間での反応” 大野 祥平, 有澤 光弘* 有機合成化学協会誌，Vol. 79, No.1 (2021), 22-33. “Carbo─ and Heterocycle Syntheses via Reactions between Two Multiple Bonds; Involving Heteroatom─Substituted Unsaturated Bonds” Shohei Ohno, Mitsuhiro Arisawa* J. Synth. Org. Chem. Jpn. 2021, 79, 22-33. DOI: 10.5059/yukigoseikyokaishi.79.22  |
| 2 |
Non-directed β- or γ-C(sp3)-H Functionalization of Saturated Nitrogen-containing Heterocycles
|
| 3 | Recent Advances in Metal Nanoparticle-catalyzed Coupling Reactions Assisted by Microwave Irradiation Makoto Sako, Mitsuhiro Arisawa* Synthesis 2021, 53, 3513-3521. DOI: 10.1055/a-1505-0916  |
| 4 | C-F結合活性化によるジフルオロメチレン基の不斉非対称化 山田 真希人 ファルマシア, Vol. 57, No.6 (2021), 542. DOI: 10.14894/faruawpsj.57.6_542 |
| 5 | N-保護アミノ酸を配位子として用いた炭素（sp3）-水素結合活性化反応 吉岡 祥平 有機合成化学協会誌, Vol. 79, No. 7 (2021), 694-695. DOI: 10.5059/yukigoseikyokaishi.79.694 |
| 6 | アーヘン工科大学での研究と生活 佐古 真 Organometallic News, No. 3 (2021), 82-83. https://kinka.or.jp/om/omnews_archive/2021_03.html |
| 7 | （注目の論文）分子から窒素を引っこ抜け！第二級アミンの分子骨格編集反応の開発 佐古 真 化学, Vol. 76, No. 10 (2021), 70-71. https://www.kagakudojin.co.jp/book/b591529.html |
| Ⅲ. | Winning Prize |
| 1 | 第５回 Yoshida Prize Symposium Distinguished Lecture 有澤教授が国際有機化学財団（International Organic Chemistry Foundation; IOCF）第５回吉田賞シンポジウムで、Distinguished Lectureを受賞しました。 「Self-Assembled Multilayer-Stabilized Metal Nanoparticle Catalyst for Functional Molecular Synthesis: in-situ Metal Nanoparticle and Nanospace Simultaneous Organization」 https://iocf.sbchem.kyoto-u.ac.jp   |
