大阪大学薬学部 分子合成化学分野

2017 Publications

 

 

I. Paper
1 An Entry to Chiral 1,1,2,3-Tetrasubstituted Arylcyclopropanes by Pd(II)-Catalyzed Arylation via Directing Group-Mediated C(sp3)-H Activation
Naoyuki Hoshiya, Moemi Kondo, Hayato Fukuda, Mitsuhiro Arisawa, Jun’ichi Uenishi, and Satoshi Shuto.
J. Org. Chem. 2017,82, 535–2544. DOI:10.1021/acs.joc.6b02935
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2 Cyclopropane-Based Peptidomimetics Mimicking Wide-Ranging Secondary Structures of Peptides: Conformational Analysis and Their Use in Rational Ligand Optimization
Akira Mizuno, Tomoshi Kameda, Tomoki Kuwahara, Hideyuki Endoh, Yoshihiko Ito, Shizuo Yamada, Kimiko Hasegawa, Akihito Yamano, Mizuki Watanabe, Mitsuhiro Arisawa, Satoshi Shuto.
Chem. Eur. J. 2017, 23, 3156-3168. DOI: 10.1002/chem.201605312
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3 First Asymmetric Total Synthesis and Insight into the Structure of
Laurenidificin

Yusuke Yoshikawa, Maki Yamakawa, Tetsuya Kobayashi, Kunio Suzuki, Mitsuhiro Arisawa, Hiromichi Fujioka.
Eur. J. Org. Chem. 2017, 19, 2715-2718.DOI: 10.1002/ejoc.201700321
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4 Cycloisomerization between Aryl Enol Ether and Silylalkynes under
Ruthenium Hydride Catalysis: Synthesis of 2,3-Disubstituted Benzofurans

Shohei Ohno, Kohei Takamoto, Hiromichi Fujioka, Mitsuhiro Arisawa
Org. Lett. 2017, 19, 2422-2425.DOI: 10.1021/acs.orglett.7b00985
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5 One-pot Enyne Metathesis/Diels–Alder/Oxidation to Six-membered
Silacycles with a Multi-ring Core: Discovery of Novel Fluorophores

Shohei Yoshioka, Yuki Fujii, Hirofumi Fujino, Tadayuki Uno, Hiromichi
Fujioka, Mitsuhiro Arisawa
Chem. Commun. 2017, 53, 5970-5973. DOI: 10.1039/C7CC02788E
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6 Ligand-Free Suzuki–Miyaura Coupling Using Ruthenium(0) Nanoparticles and a Continuously Irradiating Microwave System
Toshiki Akiyama, Takahisa Taniguchi, Nozomi Saito, Ryohei Doi, Tetsuo Honma, Yusuke Tamenori, Yuuta Ohki, Naoyuki Takahashi, Hiromichi Fujioka, Yoshihiro Sato, Mitsuhiro Arisawa
Green Chem. 2017, 19, 3357-3369.DOI: 10.1039/C7GC01166K
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7 Concise synthesis of oxacyclic compounds using highly discriminative two-way transformations of α,β-unsaturated esters in the presence of enones
Kenta Morita, Reiya Ohta, Hiroshi Aoyama, Kenzo Yahata, Mitsuhiro Arisawa, Hiromichi Fujioka
Chem. Commun. 2017, 53, 6605-5508. DOI: 10.1039/C7CC03287K
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8 Transformation of Methylene Acetals to Bromoformates with a Combination of Trimethyl(phenylthio)silane and N-Bromosuccinimide
Satoshi Takano, Takayoshi Tsuzuki, Takashi Murayama, Tomoshi Kameda, Yasuhiro Kumaki, Takashi Sakurai, Hayato Fukuda, Mizuki Watanabe, Mitsuhiro Arisawa, Satoshi Shuto
J. Med. Chem. 2017, 60, 5868-5875.DOI: 10.1021/acs.jmedchem.7b00540
9 Synthesis of 8-Substituted Analogues of Cyclic ADP-4-Thioribose and Their Unexpected Identification as Ca2+-Mobilizing Full Agonists
Tomohiro Megawa, Misa Nogata, Yuuka Hirose, Shun Ohgami, Akira Nakamura, Yasuyoshi Miki, and Hiromichi Fujioka
J. Org. Chem., 2017, 82 (14), pp 7608–7613.DOI: 10.1021/acs.joc.7b00776
10 Ruthenium-Catalyzed 1,6-Aromatic Enamide−Silylalkyne Cycloisomerization: Approach to 2,3-Disubstituted Indoles
Kohei Takamoto, Shohei Ohno, Norimichi Hyogo, Hiromichi Fujioka, and Mitsuhiro Arisawa
J. Org. Chem. 2017, 82. 8733-8742. DOI: 10.1021/acs.joc.7b01288
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11 Versatile and chemoselective synthesis of fluorinated methyl ethers from methoxymethyl ethers
Reiya Ohta, Yuichi Kuboki, Yuki Yoshikawa, Yasuyuki Koutani, Tomohiro Maegawa, Hiromichi Fujioka
Journal of Fluorine Chemistry, 2017, 201, 1-6.DOI:org/10.1016/j.jfluchem.2017.07.007
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12 Synthesis of 8-Substituted Analogues of Cyclic ADP-4-Thioribose and Their Unexpected Identification as Ca2+-Mobilizing Full Agonists
Satoshi Takano, Takayoshi Tsuzuki, Takashi Murayama, Tomoshi Kameda, Yasuhiro Kumaki, Takashi Sakurai, Hayato Fukuda, Mizuki Watanabe, Mitsuhiro Arisawa, Satoshi Shuto
Journal of Medicical Chemistry, 2017, 60, 5868-5875.DOI:10.1021/acs.jmedchem.7b00540
13 Transformation of Methylene Acetals to Bromoformates with a Combination of Trimethyl(phenylthio)silane and N-Bromosuccinimide
Tomohiro Maegawa, Misa Nogata, Yuuka Hirose, Shun Ohgami, Akira Nakamura, Yasuyoshi Miki, Hiromichi Fujioka
Journal of Organic Chemistry, 2017, 82, 7608-7613.DOI:10.1021/acs.joc.7b00776
14 Enantio- and Diastereoselective Betti/aza-Michael Sequence: Single Operated Preparation of Chiral 1,3-Disubstituted Isoindolines
Shinobu Takizawa, Makoto Sako, Mohamed Ahmed Abozeid, Kenta Kishi, H. D. P. Wathsala, Shuichi Hirata, Kenichi Murai, Hiromichi Fujioka, Hiroaki Sasai
Organic Letters, 2017, 19, 5426–5429.DOI:10.1021/acs.orglett.7b02693
II. Review
1 エナミドメタセシス反応を用いたインドメタシン誘導体の合成と多剤耐性抗がん剤への展開
Mitsuhiro Arisawa
Biophila 2017, 6, 29-39.
2 Chemoselective reduction and alkylation of carbonyl functions using phosphonium salts as an in situ protecting groups
Reiya Ohta, Hiromichi Fujioka
Chem. Pharm. Bull. 2017, 65, 10-18.
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Ⅲ. Winning Prize
1 第43回反応と合成の進歩シンポジウム・富山学生ポスター賞受賞
M2の窪木さんが富山学生ポスター賞を受賞されました。おめでとうございます。
http://www.43spors.jp/common/pdf/winning/student_poster.pdf 
2 大阪大学賞受賞
有澤准教授が平成29年度大阪大学賞を受賞することになりました。
http://www.phs.osaka-u.ac.jp/information/topics_detail.cgi?id=1511758954